A couple with normal phenotype has been married for 3 years with three spontaneous abortions but the karyotype analysis showed no obvious abnormality. According to the doctor's recommendation, the couple's 5 embryos were tested by PGT-A after ovarian hyperstimulation by drug stimulation, egg retrieval, insemination, in vitro culture of fertilized eggs, embryo biopsy, embryo freezing. The results indicated that two (No.3 and No.5) were normal and three (No.1, No.2 and No.4) were abnormal in chromosomes. Abnormalities included trisomy, monosomy and large chromosomal deletions. After a comprehensive evaluation of the two normal embryos, the doctor finally selected No.5 for implantation. 14 days after implantation, the test showed that the patient had a successful pregnancy, and the prenatal diagnosis was consistent with the PGT-A results. Finally, the pregnant woman gave birth to a healthy baby after a long gestation. Through PGT-A, the couple avoided the physiological, psychological and economic losses to the whole family brought about by repeated abortions, and also avoided the heavy burden on society caused by the babies with genetic diseases.